IRS commonly refers to the United States Internal Revenue Service.

IRS may also mean:

Economics

• International Retail Service, a service provided by the London Stock Exchange
• Indian Revenue Service (IRS)
• Interest rate swap

Medicine

• Intergroup Rhabdomyosarcoma Study Group, about the cancer, rhabdomyosarcoma
• Insulin receptor substrate, a protein family involved in the insulin signaling pathway (insulin response)
• Indoor residual spraying, the spraying of insecticide to kill the mosiquitoes that spread malaria

Music

• I.R.S. Records
• IRS (Guns N' Roses Song), a song by Guns N' Roses featured on their album, Chinese Democracy
• Insanity Reigns Supreme, abbreviated IRS, a Belgian metal band.

Space

• Indian Remote Sensing satellite

Transportation

• Independent rear suspension, used in automobiles
• An Inertial Reference System, more commonly known as an Inertial Navigation System.
• International Register of Shipping
• Industrial Railway Society, a UK railway society

Other

• Integrated reception system for TV and radio signals
• Institute of Regional Studies
• Intelligent Register System
• Irwin R. Schyster, often abbreviated I.R.S., a former professional wrestler also known as Mike Rotunda
• Interface Requirements Specification
• Intermediate Reference System as standardized in ITU-T P.48

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