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Poly vinyl pyrrolidone |
| Polyvinylpyrrolidone | |
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| IUPAC name | Polyvinylpyrrolidone |
| Other names | • 1-Ethenyl-2-pyrrolidon homopolymer • Poly[1-(2-oxo-1-pyrrolidinyl)ethylen] |
| Identifiers | |
| CAS number | [9003-39-8] |
| Properties | |
| Molecular formula | (C6H9NO)n |
| Molar mass | 111,14 g·mol−1 |
| Appearance | white to light yellow, hygroscopic, amorphous powder |
| Density | 1,2 g/cm³ |
| Melting point |
130-180 °C (glass temperature) |
| Hazards | |
| MSDS | MSDS for PVP from EMD Chemicals |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox references |
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Polyvinylpyrrolidone (PVP, povidone, polyvidone) is a water-soluble polymer made from the monomer N-Vinylpyrrolidone:
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PVP is soluble in water and other polar solvents. In water it has the useful property of Newtonian viscosity. When dry it is a light flaky powder, which readily absorbs up to 40% of its weight in atmospheric water. In solution, it has excellent wetting properties and readily forms films. This makes it good as a coating or an additive to coatings.
PVP was invented by Prof. Walter Reppe and a patent is filed in 1939 for one of the most interesting derivatves of acetylene chemistry. PVP is initially used as a blood plasma substitute and later in a wide variety of applications in medicine, pharmacy, cosmetics and industrial production.
The monomer is carcinogenic and is extremely toxic to aquatic life. However the polymer PVP in its pure form is so safe that not only is it edible by humans, but it was used as a blood plasma expander for trauma victims after the first half of 20th century.clarify
It is used as a binder in many pharmaceutical tablets; being completely inert to humans, it simply passes through the body when taken orally. PVP added to Iodine forms a complex (Povidone-iodine 5) that possesses disinfectant properties. This complex is contained in various products like solutions, ointment, pessaries, liquid soaps and surgical scrubs. It is known for instance under the trade name Betadine.
PVP binds to polar molecules exceptionally well, owing to its polarity. This has led to its application in coatings for photo-quality ink-jet papers and transparencies, as well as in inks for inkjet printers.
PVP is also used in personal care products, such as shampoos and toothpastes, in paints, and adhesives that you have to moisten, such as old-style postage stamps and envelopes. It has also been used in contact lens solutions and in steel-quenching solutions. PVP is the basis of the early formulas for hair sprays and hair gels, and still continues to be a component of some.
As a food additive, PVP is a stabilizer and has E number E1201. PVPP is E1202. It is also used in the wine industry as a fining agent for white wine. Other references state that as polyvinyl pyrrolidone and its derivatives are fully from mineral synthetic[1] origin. Therefore, its use in the production should not be a problem for vegans.
In molecular biology, PVP can be used as a blocking agent during Southern blot analysis as a component of Denhardt's buffer. It is also exceptionally good at adsorbing polyphenols during DNA purification. Polyphenols are common in many plant tissues and can deactivate proteins if not removed and therefore inhibit many downstream reactions like PCR.
PVP is also used in many technical applications:
A cross-linked form of PVP is also used as a disintegrant (see also excipients) in pharmaceutical tablets 1,4. Is is also known as cross-linked polyvinyl pyrrolidone, Polyvinyl Polypyrrolidone (PVPP), crospovidone, crospolividone. Basically, PVPP is a highly cross-linked version of PVP, which makes it insoluble in water but it still absorbs water and swells very rapidly and generate a swelling force. That is why it can be used a disintegrant in tablets. It is also used to bind impurities to remove them from solutions.It is also used as a fining to extract impurities (via agglomeration followed by filtration). Using the same principle it is uses to remove polyphenols in beer production and thus clear beers with stable foam are produced.[2] PVPP can be used as well as a drug taken as a tablet or suspension and it absorbs compounds (so called Endotoxins) causing diarrhoea. (Cf. bone char, charcoal.)
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